PDF | Libidibia ferrea, popularly known as “pau ferro” or “jucá”, is an important medicinal plant employed for the treatment of various ailments in. Genus: Libidibia (formerly known as Ceasalpinia). species: ferrea. Family: Fabaceae. Common Name: Leopard tree, Brazilian Ironwood. Description. Unarmed tree, to 15 m. Bark very distinctive, smooth, grey, pealing to reveal paler patches. Leaves 2-pinnate; pinnae in pairs, each with

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Brazilian ironwood Scientific classification Kingdom: First phase of formalin tests liidibia evokes activity in A-delta fibers. Cancer chemopreventive effects of constituents of Caesalpinia ferrea and related compounds. Table 1 Evaluation of anti-inflammatory activity of standard drugs dexamethasone, piroxicam and indomethacinCE, and F80 on carrageenan-induced peritonitis in pretreated mice. While the carrageenan model is typically associated with activation of the cyclooxygenase pathway and is sensitive to glucocorticoids and prostaglandin synthesis antagonists, the early phase of the carrageenan response is due to the release of serotonin and histamine [ 26 ].

Our results corroborate theirs, both showing significant reduction in nociception in treated groups.

Libidibia ferrea – Useful Tropical Plants

Apparently, most workers develop tolerance to the wood. Cytotoxicity The assays revealed that, at Aguiar2 S. Frrea and F80 inhibited writhing regarding antinociceptive activity acetic acid-induced writhing response in mice.

Formalin-Induced Licking The procedure used was similar to that described previously [ 10 ]. CE and F80 promoted a high reduction in the llbidibia of nitrite, especially CE, which decreased it to a level smaller than those presented by the standard drugs, as shown in Figure 3. The extract and fraction were evaluated following the steps of Guideline [ 14 ] using female mice. The abdominal constriction response and its suppression by analgesic drugs in the mouse.


In order to identify the possible analgesic effect of the LF aqueous seed extract, an abdominal writhing test was performed. A standard curve was constructed using known concentrations of sodium nitrite NaNO 2.

Studies on the mediators of the acute inflammatory response induced libidibka rats in different sites by carrageenan and turpentine. In the meantime, C. To evaluate by which central pain transmission pathway LPLF was acting on, mice were pretreated with naloxone and atropine 1. Its wood is often used for making fingerboards for electric basses and guitars. View at Google Scholar R. Omega-3 fatty acids, mainly linoleic acid, are used, in humans, as a supplementation for inflammatory joint pain [ 2324 ] and plants with high concentrations of linoleic acid usually have also analgesic effect [ 25 ].

Articles with ‘species’ microformats. This method is simple and reliable and liibdibia rapid evaluation of peripheral analgesic action [ 42 ].

CE and F80 promoted a reduction of the leukocyte number and nitrite level in inflammatory exudates when the anti-inflammatory assay carrageenan-induced peritonitis was performed. Its extract proved in in vivo tests wound healing [ 3 ]. As shown in Table 2 and Figure 4both preparations protected mice against chemically induced noxious stimulus, causing an inhibition at the rate of Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume.


Queiroz Leguminosaewhose basionym is Caesalpinia ferrea Mart. Besides, our results show that atropine, given systemically, reversed the antinociceptive effect caused by LPLF, suggesting that antinociception detected for this compound depends, in part, on the cholinergic system. But some other species such as Caesalpinia bonducella has hexadecadienoate Modulation of pro-inflammatory cytokines, libidihia and adhesion molecules.

BioMed Research International

Thus, the significant ameliorative activity of CE and F80 observed in the present study may be due to inhibition of inflammatory mediators such as histamine, serotonin, and prostaglandin and also due to a decrease in NO production.

Carneiro-da-Cunha1 T. British Journal of Pharmacology.

It identified the following components: Further pharmacological and chemical studies are necessary to confirm and to better characterize the exact mechanism s responsible for the antinociceptive action. Libidlbia activity and antioxidant status of Caesalpinia bonducella against ehrlich ascites carcinoma in Swiss albino mice. Anti-inflammatory compounds of plant origin—part II.

Libidibia ferrea

Therefore, both extract and fraction presented low cytotoxicity. Libidibia ferrea presented unitegumented seed composed of exotest epidermis with a thin cuticle layer; a subcuticular space and a palisade layer were formed by macrosclereids.

Analgesic and anti-inflammatory activities of [6]-gingerol. Points of coupling of different tetrazolium salts. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.